The Cancer Intervention and Surveillance Modeling Network (CISNET) is a consortium of NCI-sponsored investigators that includes modeling to improve our understanding of the impact of cancer control interventions (e.g., prevention, screening, and treatment) on population trends in incidence and mortality. These models can be used to project future trends and aid in the development of optimal cancer control strategies. They can also be used to guide public health research and priorities. Established in 2000 by the National Cancer Institute (NCI), CISNET’s projects comprise the following cancer sites: breast, cervical, colorectal, esophagus, lung, and prostate.